Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide
OAZ1
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN5511408
Quick Overview for Ornithine Decarboxylase Antizyme 1 (OAZ1) (Middle Region) Peptide (ABIN5511408)
Target
OAZ1
(Ornithine Decarboxylase Antizyme 1 (OAZ1))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- PHPPLKIPGG RGNSQRDHSL SASILYSDER LNVTEEPTSN DKTRVLSIQS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Oaz1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))
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Background
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The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.
Alias Symbols: AZ1, Oaz, AZ-1, ODC-Az, Antizyme
Protein Size: 227 -
Gene ID
- 18245
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NCBI Accession
- NM_008753, NP_032779
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UniProt
- P54369
Target
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